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Backed by science

Multiple studies have shown Peptan’s significant ability to promote joint and bone health and as a pure protein, it promotes muscle mass too, helping to reduce the impact of common mobility-limiting, age-related conditions. 

Improved joint function and reduced discomfort

Collagen fibers make up between 70 and 95 per cent of cartilage and are responsible for its structure and strength. Following ingestion, collagen peptides rapidly accumulate in cartilage and provide a pool of specific amino-acids to promote endogenous collagen synthesis1. This process may act to reduce the cartilage degrading effects. 

A 2013 placebo-controlled clinical trial has found that an 8g daily dose of Peptan significantly lower joint discomfort and increase joint function and flexibility. The joint health improvements were recorded after three months of intake and further enhanced after six months2. Numerous additional clinical studies have shown similar effects, with multiple trials also demonstrating that subjects with severe joint deterioration benefit even further from the effects of collagen peptides3-4.

Dense and strong bones

Representing 90 per cent of organic bone mass, collagen is a key bone component, responsible for the structural framework upon which minerals are deposited. 

Collagen peptides have been shown to stimulate the production of collagen by bone cells, leading to higher levels of new bone tissue formation5. Additionally, in vivo studies from 2010 and 2012 have demonstrated that supplementing the diet with Peptan improves bone metabolism and biomechanical parameters to promote denser and stronger bones6-7. It can also be combined with calcium and vitamin D to offer further significant health benefits.

Muscle regeneration

The consumption of adequate dietary protein is crucial for counteracting the muscle-reducing effects of sarcopenia – the loss of lean muscle mass and strength with age. Today, the recommended intake of protein is 1g/kg of body weight per day, but an international expert panel suggests elderly people can benefit from more protein and is calling for 1.2 g/kg – often higher than the typical diet of an older person8.

1 Oesser, et al., 1999, Oral Administration of 14C Labelled Gelatine Hydroslysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL), Journal of Nutrition, 129: 1891-1895, and Oesser, S. et al.., 2003, Stimulation of Type II Collagen Biosynthesis and Secretion in Bovine Chandrocytes Cultured with Degraded Collagen, Cell Tissue Research, 311: 393-399 -  
2 Jiang JX. et al., Collagen Peptides improve  knee osteoarthritis in elderly women. A six month randomised double-blind, placebo-controlled study, Agro FOOD Industry Hi Tech Vol 25(2), March/April 2014 -   
3 Moskowitz, R., 2000, Role of Collagen Hyrolysate in Bone and Joint Disease, Seminars in Arthritis and Rheumatism, 30 (2):8-99  
4 Ruiz-Bento, P.,  et al., L.A., 2009, A Randomized Controlled Trial on the Efficacy and Safety of a Food Ingredient, Collagen Hydrolysate, for Improving Joint Comfort, International Journal of Food Science and Nutrition  - 
Mizuno, M., et al., 2001, Osteoblast-Related Gene Expression of Bone Marrow Cells During the Osteoblast Differentiation Induced by Type I Collagen, Journal of Biochemistry, 129: 133-138
6 Guillerminet, F., et al., 2010, Collagen Peptides Improves Bone Metabolism and Biomechanical Parameters in Ovarietomized Mice: An In-Vitro and In Vivo Study, Bone
7 Guillerminet F. et al., 2012, Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice. Osteoporosis International, 23: 1909–1919
8 Clinical Nutrition – 2014 - Protein intake and exercise for optimal muscle function with aging: Recommendations for the ESPEN Expert Group

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